SLC45A2
SLC45A2 (Membrane-associated transporter protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Melanoma and Basal cell carcinoma. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Proton-associated glucose and sucrose transporter. May be able to transport also fructose. Expressed at a late melanosome maturation stage where functions as proton/glucose exporter which increase lumenal pH by decreasing glycolysis. Regulates melanogenesis by maintaining melanosome neutralisation that is initially initiated by transient OCA2 and required for a proper function of the tyrosinase TYR. Location: Melanosome membrane (UniProt). Locus 5p13.2 (HGNC).
- Skin cancer: Open Targets association 0.59 with skin cancer (MONDO_0002898)
- Melanoma: Open Targets association 0.55 with melanoma (MONDO_0005105)
- Basal cell carcinoma: Open Targets association 0.51 with basal cell carcinoma (MONDO_0020804)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"SLC45A2" OR ABSTRACT:"SLC45A2" OR TITLE:"solute carrier family 45 member 2" OR ABSTRACT:"solute carrier family 45 member 2" OR TITLE:"Membrane-associated transporter protein" OR ABSTRACT:"Membrane-associated transporter protein" OR TITLE:"AIM-1" OR ABSTRACT:"AIM-1" OR TITLE:"OCA4" OR ABSTRACT:"OCA4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SLC45A2, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/slc45a2.json. Licence CC BY-NC 4.0.