RBFOX1
RBFOX1 (RNA binding protein fox-1 homolog 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer.
Overview
RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.83, animal model 0.32, genetic association 0.66, somatic mutation 0.25). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Prostate Adenocarcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · RBFOX1 (RNA binding protein fox-1 homolog 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer.
- 1 · What it is
RBFOX1 (RNA binding protein fox-1 homolog 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer.
- 2 · What goes wrong in cancer
RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.
- 3 · How drugs use it
No product in this corpus aims at RBFOX1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:18222 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NWB1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000078328 (association with cancer (MONDO_0004992) 0.53; (GraphQL API, CC0)); IntOGen RBFOX1 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis. Location: Nucleus; Cytoplasm (UniProt). Locus 16p13.3 (HGNC).
- Prostate cancer: IntOGen driver in 1 cohort (PRAD)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"RBFOX1" OR ABSTRACT:"RBFOX1" OR TITLE:"RNA binding fox-1 homolog 1" OR ABSTRACT:"RNA binding fox-1 homolog 1" OR TITLE:"RNA binding protein fox-1 homolog 1" OR ABSTRACT:"RNA binding protein fox-1 homolog 1" OR TITLE:"A2BP1" OR ABSTRACT:"A2BP1" OR TITLE:"FOX-1" OR ABSTRACT:"FOX-1" OR TITLE:"HRNBP1" OR ABSTRACT:"HRNBP1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RBFOX1, not a curated reading list.