PLXNC1
PLXNC1 (Plexin-C1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.
Overview
Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Melanoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PLXNC1 (Plexin-C1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.
- 1 · What it is
PLXNC1 (Plexin-C1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.
- 2 · What goes wrong in cancer
Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein.
- 3 · How drugs use it
No product in this corpus aims at PLXNC1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:9106 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O60486 (protein name, function text, keywords and locations (REST API)); IntOGen PLXNC1 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8. Location: Membrane (UniProt). Locus 12q22 (HGNC).
- Melanoma: IntOGen driver in 1 cohort (MEL)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PLXNC1" OR ABSTRACT:"PLXNC1" OR TITLE:"plexin C1" OR ABSTRACT:"plexin C1" OR TITLE:"Plexin-C1" OR ABSTRACT:"Plexin-C1" OR TITLE:"VESPR" OR ABSTRACT:"VESPR" OR TITLE:"CD232" OR ABSTRACT:"CD232") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PLXNC1, not a curated reading list.