CADM2
CADM2 (Cell adhesion molecule 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.
Overview
Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organisation, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Melanoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CADM2 (Cell adhesion molecule 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.
- 1 · What it is
CADM2 (Cell adhesion molecule 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.
- 2 · What goes wrong in cancer
Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organisation, providing regulated trans-synaptic adhesion.
- 3 · How drugs use it
No product in this corpus aims at CADM2 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:29849 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8N3J6 (protein name, function text, keywords and locations (REST API)); IntOGen CADM2 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organisation, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes. Interacts with measles hemagglutinin to trigger hyperfusogenic F-mediated membrane fusion and presumably transsynaptic cell-to-cell transmission of the virus. Location: Cell membrane; Synapse; Cell projection, axon (UniProt). Locus 3p12.1 (HGNC).
- Melanoma: IntOGen driver in 1 cohort (MEL)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CADM2" OR ABSTRACT:"CADM2" OR TITLE:"cell adhesion molecule 2" OR ABSTRACT:"cell adhesion molecule 2" OR TITLE:"Cell adhesion molecule 2" OR ABSTRACT:"Cell adhesion molecule 2" OR TITLE:"NECL3" OR ABSTRACT:"NECL3" OR TITLE:"Necl-3" OR ABSTRACT:"Necl-3" OR TITLE:"SynCAM2" OR ABSTRACT:"SynCAM2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CADM2, not a curated reading list.