TENT5C
TENT5C (Terminal nucleotidyltransferase 5C) is an enzyme. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Multiple myeloma, Skin cancer, Colorectal cancer and 1 more.
Overview
Catalyses the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances mRNA stability and gene expression. Can also elongate RNA oligos ending with uridine molecule, provided that the sequence is adenosine-rich. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein.
Open Targets scores its association with cancer at 0.72 (direct and indirect evidence; datatypes literature 0.92, animal model 0.44, genetic association 0.10, somatic mutation 0.92). IntOGen calls it a driver in 3 cohorts (1 activating, 2 loss-of-function), covering Plasma Cell Myeloma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TENT5C (Terminal nucleotidyltransferase 5C) is an enzyme. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Multiple myeloma, Skin cancer, Colorectal cancer and 1 more.
- 1 · What it is
TENT5C (Terminal nucleotidyltransferase 5C) is an enzyme. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Multiple myeloma, Skin cancer, Colorectal cancer and 1 more.
- 2 · What goes wrong in cancer
Catalyses the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances mRNA stability and gene expression.
- 3 · How drugs use it
No product in this corpus aims at TENT5C yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:24712 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q5VWP2 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000183508 (association with cancer (MONDO_0004992) 0.72; per-cancer scores at or above 0.5: colorectal cancer 0.51, plasma cell myeloma 0.54, skin cancer 0.52, lung cancer 0.50 (GraphQL API, CC0)); IntOGen TENT5C (driver in 3 cohorts (Act 1, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Catalyses the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances mRNA stability and gene expression. Can also elongate RNA oligos ending with uridine molecule, provided that the sequence is adenosine-rich. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein. Location: Nucleus; Cytoplasm; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (UniProt). Locus 1p12 (HGNC).
- Multiple myeloma: Open Targets association 0.54 with plasma cell myeloma (MONDO_0009693); IntOGen driver in 3 cohorts (PCM)
- Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898)
- Colorectal cancer: Open Targets association 0.51 with colorectal cancer (MONDO_0005575)
- Lung cancer: Open Targets association 0.50 with lung cancer (MONDO_0008903)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TENT5C" OR ABSTRACT:"TENT5C" OR TITLE:"terminal nucleotidyltransferase 5C" OR ABSTRACT:"terminal nucleotidyltransferase 5C" OR TITLE:"Terminal nucleotidyltransferase 5C" OR ABSTRACT:"Terminal nucleotidyltransferase 5C" OR TITLE:"FLJ20202" OR ABSTRACT:"FLJ20202" OR TITLE:"FAM46C" OR ABSTRACT:"FAM46C") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TENT5C, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetIKBKB
Shares Lung cancer (all types), Skin cancer (all types), IntOGen, Multiple myeloma.
- TargetAFDN
Shares Lung cancer (all types), Skin cancer (all types), IntOGen, Open Targets Platform.
- TargetATP2B3
Shares Lung cancer (all types), Skin cancer (all types), IntOGen, Open Targets Platform.
- TargetAFF4
Shares Lung cancer (all types), Skin cancer (all types), IntOGen, Open Targets Platform.
- TargetFUBP1
Shares Lung cancer (all types), Skin cancer (all types), IntOGen, Open Targets Platform.
- TargetSOX2
Shares Lung cancer (all types), Skin cancer (all types), Open Targets Platform, Colorectal cancer.
- TargetACVR1B
Shares Lung cancer (all types), Skin cancer (all types), IntOGen, Open Targets Platform.
- TargetIRS4
Shares Lung cancer (all types), Skin cancer (all types), IntOGen, Open Targets Platform.