SIRPA
SIRPA (Tyrosine-protein phosphatase non-receptor type substrate 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Cervical cancer, Colorectal cancer, Non-Hodgkin lymphoma and 1 more.
Overview
Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment.
IntOGen calls it a driver in 5 cohorts (4 activating, 1 loss-of-function), covering Acute Myeloid Leukaemia, Cervical Squamous Cell Carcinoma, Colorectal Adenocarcinoma, High-Grade Glioma, NOS, Malignant Lymphoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SIRPA (Tyrosine-protein phosphatase non-receptor type substrate 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Cervical cancer, Colorectal cancer, Non-Hodgkin lymphoma and 1 more.
- 1 · What it is
SIRPA (Tyrosine-protein phosphatase non-receptor type substrate 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Cervical cancer, Colorectal cancer, Non-Hodgkin lymphoma and 1 more.
- 2 · What goes wrong in cancer
Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane.
- 3 · How drugs use it
No product in this corpus aims at SIRPA yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:9662 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P78324 (protein name, function text, keywords and locations (REST API)); IntOGen SIRPA (driver in 5 cohorts (Act 4, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signalling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. Location: Membrane (UniProt). Locus 20p13 (HGNC).
- Cervical cancer: IntOGen driver in 1 cohort (CESC)
- Colorectal cancer: IntOGen driver in 1 cohort (COADREAD)
- Non-Hodgkin lymphoma: IntOGen driver in 1 cohort (MLYM)
- Acute myeloid leukaemia: IntOGen driver in 1 cohort (AML)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 4 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: High-Grade Glioma, NOS.
Latest papers
topQuery for this target: (TITLE:"SIRPA" OR ABSTRACT:"SIRPA" OR TITLE:"signal regulatory protein alpha" OR ABSTRACT:"signal regulatory protein alpha" OR TITLE:"Tyrosine-protein phosphatase non-receptor type substrate 1" OR ABSTRACT:"Tyrosine-protein phosphatase non-receptor type substrate 1" OR TITLE:"SHPS1" OR ABSTRACT:"SHPS1" OR TITLE:"MYD-1" OR ABSTRACT:"MYD-1" OR TITLE:"P84" OR ABSTRACT:"P84") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SIRPA, not a curated reading list.