Siglec-10
Siglec-10 is the receptor on macrophages and other blood cells that reads the CD24 'don't eat me' badge on tumour cells and calls off the attack.
Overview
SIGLEC10 (chromosome 19q13.41) is a sialic-acid-binding immunoglobulin-like lectin that preferentially binds alpha-2,3- or alpha-2,6-linked sialic acid and seems to act as an inhibitory receptor in the immune response, recruiting cytoplasmic phosphatases through its ITIMs on ligand-induced phosphorylation; it is expressed by peripheral blood leukocytes (eosinophils, monocytes and an NK-cell subpopulation) and in lymph node, lung, ovary and appendix (UniProt Q96LC7). The CD24-Siglec-10 interaction inhibits macrophage phagocytosis and NK cytotoxicity (Panagiotou et al. 2022).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · Siglec-10 is the receptor on macrophages and other blood cells that reads the CD24 'don't eat me' badge on tumour cells and calls off the attack.
- 1 · What it is
Siglec-10 is the receptor on macrophages and other blood cells that reads the CD24 'don't eat me' badge on tumour cells and calls off the attack.
- 2 · What goes wrong in cancer
An ITIM-bearing Siglec; the receptor half of the CD24 pair.
- 3 · How drugs use it
No product in this corpus aims at Siglec-10 yet. Checkpoint drugs are antibodies that cover one side of an immune ‘stand down’ handshake so T cells stay active.
External identifiers
Sources: HGNC HGNC:15620 (approved symbol, name, aliases and cross-references); UniProt Q96LC7 (protein name, function and tissue specificity)
Biology
An ITIM-bearing Siglec; the receptor half of the CD24 pair.
- Eosinophils, monocytes, an NK subpopulation (UniProt Q96LC7)
Notes
top- Prevalence not recorded: HGNC and UniProt carry no positivity rates.
Latest papers
topQuery for this target: (TITLE:"Siglec-10" OR ABSTRACT:"Siglec-10" OR TITLE:"SIGLEC10" OR ABSTRACT:"SIGLEC10" OR TITLE:"SIGLEC-10" OR ABSTRACT:"SIGLEC-10" OR TITLE:"sialic acid binding Ig like lectin 10" OR ABSTRACT:"sialic acid binding Ig like lectin 10" OR TITLE:"SLG2" OR ABSTRACT:"SLG2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Siglec-10, not a curated reading list.
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