LILRB2 (ILT4)

aka ILT4, LIR-2, CD85d, leukocyte immunoglobulin like receptor B2

LILRB2 is a brake on monocytes and dendritic cells that reads HLA-G and other HLA class I molecules and keeps them in a tolerant, tumour-friendly state. The antibody MK-4830 blocks it and is in phase 2 with pembrolizumab.

Checkpoint familiesInnate 'don't eat me' checkpoints

LILRB2 (chromosome 19q13.42) is a receptor for class I MHC antigens across HLA-A, B, C, G and F that is involved in down-regulating the immune response and developing tolerance, and recognises peptide-bound HLA-G with beta-2 microglobulin; it is expressed in monocytes, at lower levels in myeloid and plasmacytoid dendritic cells, in tolerogenic IL-10-producing dendritic cells, in myeloid-derived suppressor cells during pregnancy, at low levels in NK cells and in B cells (UniProt Q8N423). MK-4830 is in phase 2 studies with pembrolizumab, including a completed study with chemotherapy in ovarian cancer (NCT05446870) and a platform study in solid tumours (NCT04895722).

LILRB2 (ILT4): what it is and how drugs act on it · animated schematic, not to scale

Target · the protein and the cell it sits on
Drug · antibody, small molecule, cell or radioligand
Effect · signal, damage or kill

In plain words · LILRB2 is a brake on monocytes and dendritic cells that reads HLA-G and other HLA class I molecules and keeps them in a tolerant, tumour-friendly state. The antibody MK-4830 blocks it and is in phase 2 with pembrolizumab.

1 · What it is
LILRB2 is a brake on monocytes and dendritic cells that reads HLA-G and other HLA class I molecules and keeps them in a tolerant, tumour-friendly state. The antibody MK-4830 blocks it and is in phase 2 with pembrolizumab.
2 · What goes wrong in cancer
An ITIM-bearing LILR of myeloid cells; the murine orthologue PIRB regulates myeloid-derived suppressor cell development and a tumour-permissive microenvironment (van der Touw et al. 2017).
3 · How drugs use it
No product in this corpus aims at LILRB2 (ILT4) yet. Checkpoint drugs are antibodies that cover one side of an immune ‘stand down’ handshake so T cells stay active.

Full dossier: hotspots, trials, resistance, assays, models, open questions →

Immune checkpoint All cancer genes by role →

External identifiers

LILRB2HGNCEnsemblUniProtAlphaFold DBOpen TargetsCIViCOncoKBCOSMICcBioPortalDepMapHuman Protein AtlasNCBI GeneOMIM

Sources: HGNC HGNC:6606 (approved symbol, name, aliases and cross-references); UniProt Q8N423 (protein name, function and tissue specificity)

Biology

An ITIM-bearing LILR of myeloid cells; the murine orthologue PIRB regulates myeloid-derived suppressor cell development and a tumour-permissive microenvironment (van der Touw et al. 2017).

Where it is found