HHLA2 (B7-H7)

aka B7-H7, B7H7, B7-H5, B7y, HHLA2 member of B7 family

HHLA2 is a B7 relative found on gut, kidney and lung tissue and on many tumours; it can both encourage and restrain T cells depending on the receptor. No drug against it is in the corpus yet.

Checkpoint familiesOther B7 family members

HHLA2 (chromosome 3q13.13) costimulates T cells through TMIGD2 in the context of TCR-mediated activation, enhancing proliferation and cytokine production through an AKT-dependent cascade; it is expressed at high levels in colon, kidney, testis, lung and pancreas, at lower levels in small intestine, liver and skeletal muscle, and among immune cells in B cells, dendritic cells and macrophages but not T cells (UniProt Q9UM44). B7-H3, B7x and HHLA2 form the third group of the B7-CD28 family, with antagonistic antibodies and agonistic fusion proteins emerging (Janakiram et al. 2017, Immunol Rev).

HHLA2 (B7-H7): what it is and how drugs act on it · animated schematic, not to scale

Target · the protein and the cell it sits on
Drug · antibody, small molecule, cell or radioligand
Effect · signal, damage or kill

In plain words · HHLA2 is a B7 relative found on gut, kidney and lung tissue and on many tumours; it can both encourage and restrain T cells depending on the receptor. No drug against it is in the corpus yet.

1 · What it is
HHLA2 is a B7 relative found on gut, kidney and lung tissue and on many tumours; it can both encourage and restrain T cells depending on the receptor. No drug against it is in the corpus yet.
2 · What goes wrong in cancer
A group III B7 family member; its costimulatory receptor is TMIGD2 (CD28H).
3 · How drugs use it
No product in this corpus aims at HHLA2 (B7-H7) yet. Checkpoint drugs are antibodies that cover one side of an immune ‘stand down’ handshake so T cells stay active.