CD24
CD24 is a second 'don't eat me' badge after CD47: tumours show it to Siglec-10 on macrophages, which then leave them alone. Blocking antibodies are in first-in-human trials.
Overview
CD24 (chromosome 6q21) is a small GPI-anchored glycoprotein expressed on B cells and the T-cell surface and in erythroleukaemia and small-cell lung carcinoma cell lines; it modulates B-cell activation (UniProt P25063). Normally expressed by immune, epithelial, neural and muscle cells, its interaction with Siglec-10 has been implicated in tumour immune evasion, inhibiting macrophage-mediated phagocytosis as well as NK-cell cytotoxicity; monoclonal antibodies against CD24 have shown clinical safety in two trials, with limited efficacy data (Panagiotou et al. 2022). IMM47, an anti-CD24 antibody, entered a phase 1 study in advanced solid tumours (NCT05985083, status unknown).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CD24 is a second 'don't eat me' badge after CD47: tumours show it to Siglec-10 on macrophages, which then leave them alone. Blocking antibodies are in first-in-human trials.
- 1 · What it is
CD24 is a second 'don't eat me' badge after CD47: tumours show it to Siglec-10 on macrophages, which then leave them alone. Blocking antibodies are in first-in-human trials.
- 2 · What goes wrong in cancer
A heavily glycosylated GPI-anchored surface protein; the ligand of Siglec-10.
- 3 · How drugs use it
No product in this corpus aims at CD24 yet. Checkpoint drugs are antibodies that cover one side of an immune ‘stand down’ handshake so T cells stay active.
External identifiers
Sources: HGNC HGNC:1645 (approved symbol, name, aliases and cross-references); UniProt P25063 (protein name, function and tissue specificity)
Biology
A heavily glycosylated GPI-anchored surface protein; the ligand of Siglec-10.
- B cells, T-cell surface (UniProt P25063)
- Epithelial tumours, per the cited review
Notes
top- Prevalence not recorded: HGNC and UniProt carry no positivity rates.
Latest papers
topQuery for this target: (TITLE:"CD24" OR ABSTRACT:"CD24" OR TITLE:"CD24 molecule" OR ABSTRACT:"CD24 molecule" OR TITLE:"signal transducer CD24" OR ABSTRACT:"signal transducer CD24" OR TITLE:"CD24A" OR ABSTRACT:"CD24A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CD24, not a curated reading list.
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