SIRPA
SIRPA (Tyrosine-protein phosphatase non-receptor type substrate 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Cervical cancer, Colorectal cancer, Non-Hodgkin lymphoma and 1 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signalling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. Location: Membrane (UniProt). Locus 20p13 (HGNC).
- Cervical cancer: IntOGen driver in 1 cohort (CESC)
- Colorectal cancer: IntOGen driver in 1 cohort (COADREAD)
- Non-Hodgkin lymphoma: IntOGen driver in 1 cohort (MLYM)
- Acute myeloid leukaemia: IntOGen driver in 1 cohort (AML)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"SIRPA" OR ABSTRACT:"SIRPA" OR TITLE:"signal regulatory protein alpha" OR ABSTRACT:"signal regulatory protein alpha" OR TITLE:"Tyrosine-protein phosphatase non-receptor type substrate 1" OR ABSTRACT:"Tyrosine-protein phosphatase non-receptor type substrate 1" OR TITLE:"SHPS1" OR ABSTRACT:"SHPS1" OR TITLE:"MYD-1" OR ABSTRACT:"MYD-1" OR TITLE:"P84" OR ABSTRACT:"P84") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SIRPA, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/sirpa.json. Licence CC BY-NC 4.0.