ZCRB1
ZCRB1 (Zinc finger CCHC-type and RNA-binding motif-containing protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia.
Overview
UniProt has no function text for Q8TBF4; HGNC names it "zinc finger CCHC-type and RNA binding motif containing 1".
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Acute Myeloid Leukaemia.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ZCRB1 (Zinc finger CCHC-type and RNA-binding motif-containing protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia.
- 1 · What it is
ZCRB1 (Zinc finger CCHC-type and RNA-binding motif-containing protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia.
- 2 · What goes wrong in cancer
UniProt has no function text for Q8TBF4; HGNC names it "zinc finger CCHC-type and RNA binding motif containing 1". Location: Nucleus, nucleoplasm (UniProt).
- 3 · How drugs use it
No product in this corpus aims at ZCRB1 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:29620 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8TBF4 (protein name, function text, keywords and locations (REST API)); IntOGen ZCRB1 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
UniProt has no function text for Q8TBF4; HGNC names it "zinc finger CCHC-type and RNA binding motif containing 1". Location: Nucleus, nucleoplasm (UniProt). Locus 12q12 (HGNC).
- Acute myeloid leukaemia: IntOGen driver in 1 cohort (AML)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ZCRB1" OR ABSTRACT:"ZCRB1" OR TITLE:"zinc finger CCHC-type and RNA binding motif containing 1" OR ABSTRACT:"zinc finger CCHC-type and RNA binding motif containing 1" OR TITLE:"Zinc finger CCHC-type and RNA-binding motif-containing protein 1" OR ABSTRACT:"Zinc finger CCHC-type and RNA-binding motif-containing protein 1" OR TITLE:"MADP-1" OR ABSTRACT:"MADP-1" OR TITLE:"MADP1" OR ABSTRACT:"MADP1" OR TITLE:"RBM36" OR ABSTRACT:"RBM36") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZCRB1, not a curated reading list.