RNF6
RNF6 (E3 ubiquitin-protein ligase RNF6) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer and Oesophageal cancer.
Overview
E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.08, somatic mutation 0.66, genetic literature 0.30). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Colorectal Adenocarcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · RNF6 (E3 ubiquitin-protein ligase RNF6) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer and Oesophageal cancer.
- 1 · What it is
RNF6 (E3 ubiquitin-protein ligase RNF6) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer and Oesophageal cancer.
- 2 · What goes wrong in cancer
E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover.
- 3 · How drugs use it
No product in this corpus aims at RNF6 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:10069 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9Y252 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000127870 (association with cancer (MONDO_0004992) 0.53; per-cancer scores at or above 0.5: oesophageal cancer 0.51 (GraphQL API, CC0)); IntOGen RNF6 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator. Mediates polyubiquitination of QKI in macrophages, leading to its degradation. Location: Nucleus; Cytoplasm; Cell projection, axon; Nucleus, PML body (UniProt). Locus 13q12.13 (HGNC).
- Colorectal cancer: IntOGen driver in 1 cohort (COADREAD)
- Oesophageal cancer: Open Targets association 0.51 with oesophageal cancer (MONDO_0007576)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"RNF6" OR ABSTRACT:"RNF6" OR TITLE:"ring finger protein 6" OR ABSTRACT:"ring finger protein 6" OR TITLE:"E3 ubiquitin-protein ligase RNF6" OR ABSTRACT:"E3 ubiquitin-protein ligase RNF6" OR TITLE:"DKFZp686P0776" OR ABSTRACT:"DKFZp686P0776") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RNF6, not a curated reading list.