ZNF395
ZNF395 (Zinc finger protein 395) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.
Overview
Plays a role in papillomavirus genes transcription.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Non-Small Cell Lung Cancer.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ZNF395 (Zinc finger protein 395) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.
- 1 · What it is
ZNF395 (Zinc finger protein 395) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.
- 2 · What goes wrong in cancer
Plays a role in papillomavirus genes transcription. Location: Cytoplasm; Nucleus (UniProt).
- 3 · How drugs use it
No product in this corpus aims at ZNF395 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:18737 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9H8N7 (protein name, function text, keywords and locations (REST API)); IntOGen ZNF395 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Plays a role in papillomavirus genes transcription. Location: Cytoplasm; Nucleus (UniProt). Locus 8p21.1 (HGNC).
- Non-small-cell lung cancer: IntOGen driver in 1 cohort (NSCLC)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ZNF395" OR ABSTRACT:"ZNF395" OR TITLE:"zinc finger protein 395" OR ABSTRACT:"zinc finger protein 395" OR TITLE:"Zinc finger protein 395" OR ABSTRACT:"Zinc finger protein 395" OR TITLE:"PRF-1" OR ABSTRACT:"PRF-1" OR TITLE:"HDBP2" OR ABSTRACT:"HDBP2" OR TITLE:"DKFZp434K1210" OR ABSTRACT:"DKFZp434K1210") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZNF395, not a curated reading list.