TRIP11
TRIP11 (Thyroid receptor-interacting protein 11) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer.
Overview
Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function. It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex.
Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 0.27, affected pathway 0.95, genetic association 0.00, somatic mutation 0.45). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Bladder Urothelial Carcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TRIP11 (Thyroid receptor-interacting protein 11) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer.
- 1 · What it is
TRIP11 (Thyroid receptor-interacting protein 11) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer.
- 2 · What goes wrong in cancer
Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function.
- 3 · How drugs use it
No product in this corpus aims at TRIP11 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:12305 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q15643 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000100815 (association with cancer (MONDO_0004992) 0.67; (GraphQL API, CC0)); IntOGen TRIP11 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function. It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex. Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. Location: Golgi apparatus, cis-Golgi network membrane; Cytoplasm, cytoskeleton; Endoplasmic reticulum-Golgi intermediate compartment membrane (UniProt). Locus 14q32.12 (HGNC).
- Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TRIP11" OR ABSTRACT:"TRIP11" OR TITLE:"thyroid hormone receptor interactor 11" OR ABSTRACT:"thyroid hormone receptor interactor 11" OR TITLE:"Thyroid receptor-interacting protein 11" OR ABSTRACT:"Thyroid receptor-interacting protein 11" OR TITLE:"CEV14" OR ABSTRACT:"CEV14" OR TITLE:"Trip230" OR ABSTRACT:"Trip230" OR TITLE:"GMAP-210" OR ABSTRACT:"GMAP-210") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TRIP11, not a curated reading list.