TCF12
TCF12 (Transcription factor 12) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.
Overview
Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').
IntOGen calls it a driver in 2 cohorts (0 activating, 1 loss-of-function), covering Glioblastoma Multiforme, Low-Grade Glioma, NOS.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TCF12 (Transcription factor 12) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.
- 1 · What it is
TCF12 (Transcription factor 12) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.
- 2 · What goes wrong in cancer
Transcriptional regulator. Involved in the initiation of neuronal differentiation.
- 3 · How drugs use it
No product in this corpus aims at TCF12 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:11623 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q99081 (protein name, function text, keywords and locations (REST API)); IntOGen TCF12 (driver in 2 cohorts (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). May be involved in the functional network that regulates the development of the GnRH axis. Location: Nucleus (UniProt). Locus 15q21.3 (HGNC).
- Glioma & glioblastoma: IntOGen driver in 1 cohort (GBM)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Low-Grade Glioma, NOS.
Latest papers
topQuery for this target: (TITLE:"TCF12" OR ABSTRACT:"TCF12" OR TITLE:"transcription factor 12" OR ABSTRACT:"transcription factor 12" OR TITLE:"Transcription factor 12" OR ABSTRACT:"Transcription factor 12" OR TITLE:"HTF4" OR ABSTRACT:"HTF4" OR TITLE:"HsT17266" OR ABSTRACT:"HsT17266" OR TITLE:"bHLHb20" OR ABSTRACT:"bHLHb20") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TCF12, not a curated reading list.