KLF5
KLF5 (Krueppel-like factor 5) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Bladder & urothelial cancer, Cervical cancer, Colorectal cancer and 1 more.
Overview
Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.
CIViC holds 2 clinical evidence items and 0 assertions across 2 variants. Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes affected pathway 0.44, literature 0.99, genetic association 0.70, somatic mutation 0.80, animal model 0.46). IntOGen calls it a driver in 3 cohorts (2 activating, 1 loss-of-function), covering Bladder Urothelial Carcinoma, Cervical Squamous Cell Carcinoma, Lung Squamous Cell Carcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · KLF5 (Krueppel-like factor 5) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Bladder & urothelial cancer, Cervical cancer, Colorectal cancer and 1 more.
- 1 · What it is
KLF5 (Krueppel-like factor 5) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Bladder & urothelial cancer, Cervical cancer, Colorectal cancer and 1 more.
- 2 · What goes wrong in cancer
Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.
- 3 · How drugs use it
No product in this corpus aims at KLF5 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:6349 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13887 (protein name, function text, keywords and locations (REST API)); CIViC gene KLF5 (2 evidence items, 0 assertions, 2 variants; diseases: (GraphQL API, CC0)); Open Targets ENSG00000102554 (association with cancer (MONDO_0004992) 0.69; per-cancer scores at or above 0.5: colorectal cancer 0.56 (GraphQL API, CC0)); IntOGen KLF5 (driver in 3 cohorts (Act 2, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes. Location: Nucleus (UniProt). Locus 13q22.1 (HGNC).
- Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA)
- Cervical cancer: IntOGen driver in 1 cohort (CESC)
- Colorectal cancer: Open Targets association 0.56 with colorectal cancer (MONDO_0005575)
- Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUSC)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"KLF5" OR ABSTRACT:"KLF5" OR TITLE:"KLF transcription factor 5" OR ABSTRACT:"KLF transcription factor 5" OR TITLE:"Krueppel-like factor 5" OR ABSTRACT:"Krueppel-like factor 5" OR TITLE:"BTEB2" OR ABSTRACT:"BTEB2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KLF5, not a curated reading list.