NCKIPSD
NCKIPSD (NCK-interacting protein with SH3 domain) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer.
Overview
Has an important role in stress fibre formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo. In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Endometrial Carcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · NCKIPSD (NCK-interacting protein with SH3 domain) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer.
- 1 · What it is
NCKIPSD (NCK-interacting protein with SH3 domain) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer.
- 2 · What goes wrong in cancer
Has an important role in stress fibre formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo.
- 3 · How drugs use it
No product in this corpus aims at NCKIPSD yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:15486 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NZQ3 (protein name, function text, keywords and locations (REST API)); IntOGen NCKIPSD (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Has an important role in stress fibre formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo. In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42. May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerisation and cell adhesion. Plays a role in angiogenesis. Location: Nucleus (UniProt). Locus 3p21.31 (HGNC).
- Endometrial cancer: IntOGen driver in 1 cohort (UCEC)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"NCKIPSD" OR ABSTRACT:"NCKIPSD" OR TITLE:"NCK interacting protein with SH3 domain" OR ABSTRACT:"NCK interacting protein with SH3 domain" OR TITLE:"NCK-interacting protein with SH3 domain" OR ABSTRACT:"NCK-interacting protein with SH3 domain" OR TITLE:"AF3P21" OR ABSTRACT:"AF3P21" OR TITLE:"SPIN90" OR ABSTRACT:"SPIN90" OR TITLE:"ORF1" OR ABSTRACT:"ORF1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NCKIPSD, not a curated reading list.