NCKIPSD
NCKIPSD (NCK-interacting protein with SH3 domain) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Has an important role in stress fibre formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo. In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42. May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerisation and cell adhesion. Plays a role in angiogenesis. Location: Nucleus (UniProt). Locus 3p21.31 (HGNC).
- Endometrial cancer: IntOGen driver in 1 cohort (UCEC)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"NCKIPSD" OR ABSTRACT:"NCKIPSD" OR TITLE:"NCK interacting protein with SH3 domain" OR ABSTRACT:"NCK interacting protein with SH3 domain" OR TITLE:"NCK-interacting protein with SH3 domain" OR ABSTRACT:"NCK-interacting protein with SH3 domain" OR TITLE:"AF3P21" OR ABSTRACT:"AF3P21" OR TITLE:"SPIN90" OR ABSTRACT:"SPIN90" OR TITLE:"ORF1" OR ABSTRACT:"ORF1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NCKIPSD, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/nckipsd.json. Licence CC BY-NC 4.0.