ZNF429
ZNF429 (Zinc finger protein 429) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Hepatocellular carcinoma, Prostate cancer and 1 more.
Overview
May be involved in transcriptional regulation.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.17, genetic association 0.00, somatic mutation 0.66). IntOGen calls it a driver in 4 cohorts (1 activating, 2 loss-of-function), covering Bladder Urothelial Carcinoma, Cholangiocarcinoma, Hepatocellular Carcinoma, Prostate Adenocarcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ZNF429 (Zinc finger protein 429) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Hepatocellular carcinoma, Prostate cancer and 1 more.
- 1 · What it is
ZNF429 (Zinc finger protein 429) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Hepatocellular carcinoma, Prostate cancer and 1 more.
- 2 · What goes wrong in cancer
May be involved in transcriptional regulation. Location: Nucleus (UniProt).
- 3 · How drugs use it
No product in this corpus aims at ZNF429 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:20817 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q86V71 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000197013 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0)); IntOGen ZNF429 (driver in 4 cohorts (Act 1, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
May be involved in transcriptional regulation. Location: Nucleus (UniProt). Locus 19p12 (HGNC).
- Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA)
- Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)
- Prostate cancer: IntOGen driver in 1 cohort (PRAD)
- Biliary tract cancer: IntOGen driver in 1 cohort (CHOL)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ZNF429" OR ABSTRACT:"ZNF429" OR TITLE:"zinc finger protein 429" OR ABSTRACT:"zinc finger protein 429" OR TITLE:"Zinc finger protein 429" OR ABSTRACT:"Zinc finger protein 429") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZNF429, not a curated reading list.
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