CDH11
CDH11 (Cadherin-11) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Oesophageal cancer, Gastric & gastro-oesophageal junction cancer, Colorectal cancer and 5 more.
Overview
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for proper focal adhesion assembly.
Open Targets scores its association with cancer at 0.74 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.52, somatic mutation 0.90). IntOGen calls it a driver in 7 cohorts (5 activating, 2 loss-of-function), covering Cholangiocarcinoma, Colon Adenocarcinoma, Oesophageal Adenocarcinoma, Hepatocellular Carcinoma, Lung Squamous Cell Carcinoma, Stomach Adenocarcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CDH11 (Cadherin-11) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Oesophageal cancer, Gastric & gastro-oesophageal junction cancer, Colorectal cancer and 5 more.
- 1 · What it is
CDH11 (Cadherin-11) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Oesophageal cancer, Gastric & gastro-oesophageal junction cancer, Colorectal cancer and 5 more.
- 2 · What goes wrong in cancer
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
- 3 · How drugs use it
No product in this corpus aims at CDH11 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:1750 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P55287 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000140937 (association with cancer (MONDO_0004992) 0.74; per-cancer scores at or above 0.5: gastric cancer 0.55, oesophageal cancer 0.54, skin cancer 0.51, breast cancer 0.53, biliary tract cancer 0.51 (GraphQL API, CC0)); IntOGen CDH11 (driver in 7 cohorts (Act 5, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for proper focal adhesion assembly. Involved in the regulation of cell migration. Location: Cell membrane (UniProt). Locus 16q21 (HGNC).
- Oesophageal cancer: Open Targets association 0.54 with oesophageal cancer (MONDO_0007576); IntOGen driver in 2 cohorts (ESCA)
- Gastric & gastro-oesophageal junction cancer: Open Targets association 0.55 with gastric cancer (MONDO_0001056); IntOGen driver in 1 cohort (STAD)
- Colorectal cancer: IntOGen driver in 1 cohort (COAD)
- Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)
- Breast cancer: Open Targets association 0.53 with breast cancer (MONDO_0007254)
- Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 5 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CDH11" OR ABSTRACT:"CDH11" OR TITLE:"cadherin 11" OR ABSTRACT:"cadherin 11" OR TITLE:"Cadherin-11" OR ABSTRACT:"Cadherin-11" OR TITLE:"CAD11" OR ABSTRACT:"CAD11") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CDH11, not a curated reading list.
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