BIRC3
BIRC3 (Baculoviral IAP repeat-containing protein 3) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Leukaemia, Skin cancer and 4 more.
Overview
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signalling and immunity, mitogenic kinase signalling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signalling and regulates both canonical and non-canonical NF-kappa-B signalling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signalling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10.
CIViC holds 2 clinical evidence items and 0 assertions across 2 variants. Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.00, somatic mutation 0.80, clinical 0.14). IntOGen calls it a driver in 2 cohorts (1 activating, 0 loss-of-function), covering Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma, Lung Squamous Cell Carcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · BIRC3 (Baculoviral IAP repeat-containing protein 3) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Leukaemia, Skin cancer and 4 more.
- 1 · What it is
BIRC3 (Baculoviral IAP repeat-containing protein 3) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Leukaemia, Skin cancer and 4 more.
- 2 · What goes wrong in cancer
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signalling and immunity, mitogenic kinase signalling and cell proliferation, as well as cell invasion and metastasis.
- 3 · How drugs use it
No product in this corpus aims at BIRC3 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:591 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13489 (protein name, function text, keywords and locations (REST API)); CIViC gene BIRC3 (2 evidence items, 0 assertions, 2 variants; diseases: Mantle Cell Lymphoma, Chronic Lymphocytic Leukaemia (GraphQL API, CC0)); Open Targets ENSG00000023445 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: acute lymphoblastic leukaemia 0.56, non-Hodgkin lymphoma 0.62, skin cancer 0.55, leukaemia 0.59 (GraphQL API, CC0)); IntOGen BIRC3 (driver in 2 cohorts (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signalling and immunity, mitogenic kinase signalling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signalling and regulates both canonical and non-canonical NF-kappa-B signalling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signalling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signalling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Location: Cytoplasm; Nucleus (UniProt). Locus 11q22.2 (HGNC).
- Non-Hodgkin lymphoma: Open Targets association 0.62 with non-Hodgkin lymphoma (MONDO_0018908)
- Leukaemia: Open Targets association 0.59 with leukaemia (MONDO_0005059)
- Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)
- Mantle cell lymphoma: CIViC evidence names this disease
- Chronic lymphocytic leukaemia: CIViC evidence names this disease; IntOGen driver in 1 cohort (CLLSLL)
- Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUSC)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.14; IntOGen calls it an activating (Act) driver in 1 cohort; CIViC holds 2 clinical evidence items on its variants; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"BIRC3" OR ABSTRACT:"BIRC3" OR TITLE:"baculoviral IAP repeat containing 3" OR ABSTRACT:"baculoviral IAP repeat containing 3" OR TITLE:"Baculoviral IAP repeat-containing protein 3" OR ABSTRACT:"Baculoviral IAP repeat-containing protein 3" OR TITLE:"cIAP2" OR ABSTRACT:"cIAP2" OR TITLE:"hiap-1" OR ABSTRACT:"hiap-1" OR TITLE:"RNF49" OR ABSTRACT:"RNF49") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BIRC3, not a curated reading list.
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