PCBP1
PCBP1 (Poly(rC)-binding protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer, Non-Hodgkin lymphoma, Renal cell carcinoma and 2 more.
Overview
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.21, somatic mutation 0.77). IntOGen calls it a driver in 9 cohorts (5 activating, 4 loss-of-function), covering Burkitt Lymphoma, Colon Adenocarcinoma, Colorectal Adenocarcinoma, Malignant Lymphoma, Papillary Renal Cell Carcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PCBP1 (Poly(rC)-binding protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer, Non-Hodgkin lymphoma, Renal cell carcinoma and 2 more.
- 1 · What it is
PCBP1 (Poly(rC)-binding protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer, Non-Hodgkin lymphoma, Renal cell carcinoma and 2 more.
- 2 · What goes wrong in cancer
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing.
- 3 · How drugs use it
No product in this corpus aims at PCBP1 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:8647 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q15365 (protein name, function text, keywords and locations (REST API)); CIViC gene PCBP1 (1 evidence items, 0 assertions, 1 variants; diseases: Burkitt Lymphoma (GraphQL API, CC0)); Open Targets ENSG00000169564 (association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: colorectal cancer 0.58 (GraphQL API, CC0)); IntOGen PCBP1 (driver in 9 cohorts (Act 5, LoF 4); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing. Location: Nucleus; Cytoplasm (UniProt). Locus 2p13.3 (HGNC).
- Colorectal cancer: Open Targets association 0.58 with colorectal cancer (MONDO_0005575); IntOGen driver in 5 cohorts (COAD, COADREAD)
- Non-Hodgkin lymphoma: IntOGen driver in 1 cohort (MLYM)
- Renal cell carcinoma: IntOGen driver in 1 cohort (PRCC)
- Burkitt lymphoma: CIViC evidence names this disease; IntOGen driver in 2 cohorts (BL)
- Papillary renal cell carcinoma: IntOGen driver in 1 cohort (PRCC)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 5 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 4 cohorts; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PCBP1" OR ABSTRACT:"PCBP1" OR TITLE:"poly rC binding protein 1" OR ABSTRACT:"poly rC binding protein 1" OR TITLE:"Poly rC -binding protein 1" OR ABSTRACT:"Poly rC -binding protein 1" OR TITLE:"HNRPE1" OR ABSTRACT:"HNRPE1" OR TITLE:"hnRNP-E1" OR ABSTRACT:"hnRNP-E1" OR TITLE:"HNRPX" OR ABSTRACT:"HNRPX") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PCBP1, not a curated reading list.
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