NUP214
NUP214 (Nuclear pore complex protein Nup214) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Leukaemia, Non-Hodgkin lymphoma, Renal cell carcinoma and 4 more.
Overview
Part of the nuclear pore complex. Has a critical role in nucleocytoplasmic transport. May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.94, genetic association 0.28, somatic mutation 0.76). IntOGen calls it a driver in 2 cohorts (2 activating, 0 loss-of-function), covering Papillary Renal Cell Carcinoma, Small Intestinal Carcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · NUP214 (Nuclear pore complex protein Nup214) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Leukaemia, Non-Hodgkin lymphoma, Renal cell carcinoma and 4 more.
- 1 · What it is
NUP214 (Nuclear pore complex protein Nup214) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Leukaemia, Non-Hodgkin lymphoma, Renal cell carcinoma and 4 more.
- 2 · What goes wrong in cancer
Part of the nuclear pore complex. Has a critical role in nucleocytoplasmic transport.
- 3 · How drugs use it
No product in this corpus aims at NUP214 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:8064 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P35658 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000126883 (association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: acute lymphoblastic leukaemia 0.55, non-Hodgkin lymphoma 0.59, myeloproliferative neoplasm 0.53, leukaemia 0.60 (GraphQL API, CC0)); IntOGen NUP214 (driver in 2 cohorts (Act 2, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Part of the nuclear pore complex. Has a critical role in nucleocytoplasmic transport. May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. Location: Nucleus, nuclear pore complex (UniProt). Locus 9q34.13 (HGNC).
- Leukaemia: Open Targets association 0.60 with leukaemia (MONDO_0005059)
- Non-Hodgkin lymphoma: Open Targets association 0.59 with non-Hodgkin lymphoma (MONDO_0018908)
- Renal cell carcinoma: IntOGen driver in 1 cohort (PRCC)
- Small intestine cancer: IntOGen driver in 1 cohort (SIC)
- Myeloproliferative neoplasms: Open Targets association 0.53 with myeloproliferative neoplasm (MONDO_0020076)
- Papillary renal cell carcinoma: IntOGen driver in 1 cohort (PRCC)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"NUP214" OR ABSTRACT:"NUP214" OR TITLE:"nucleoporin 214" OR ABSTRACT:"nucleoporin 214" OR TITLE:"Nuclear pore complex protein Nup214" OR ABSTRACT:"Nuclear pore complex protein Nup214" OR TITLE:"D9S46E" OR ABSTRACT:"D9S46E" OR TITLE:"N214" OR ABSTRACT:"N214") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NUP214, not a curated reading list.
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