SND1
SND1 (Staphylococcal nuclease domain-containing protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Cervical cancer, Breast cancer, Lung cancer and 3 more.
Overview
Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition. Functions as a bridging factor between STAT6 and the basal transcription factor.
Open Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes affected pathway 0.89, literature 0.98, genetic association 0.03, somatic mutation 0.83, animal model 0.38). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Cervical Squamous Cell Carcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SND1 (Staphylococcal nuclease domain-containing protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Cervical cancer, Breast cancer, Lung cancer and 3 more.
- 1 · What it is
SND1 (Staphylococcal nuclease domain-containing protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Cervical cancer, Breast cancer, Lung cancer and 3 more.
- 2 · What goes wrong in cancer
Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition.
- 3 · How drugs use it
No product in this corpus aims at SND1 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:30646 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q7KZF4 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000197157 (association with cancer (MONDO_0004992) 0.76; per-cancer scores at or above 0.5: colorectal cancer 0.52, non-Hodgkin lymphoma 0.52, breast cancer 0.56, lung cancer 0.54, leukaemia 0.51 (GraphQL API, CC0)); IntOGen SND1 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition. Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for STAT5. Location: Cytoplasm; Nucleus; Melanosome (UniProt). Locus 7q32.1 (HGNC).
- Cervical cancer: IntOGen driver in 1 cohort (CESC)
- Breast cancer: Open Targets association 0.56 with breast cancer (MONDO_0007254)
- Lung cancer: Open Targets association 0.54 with lung cancer (MONDO_0008903)
- Colorectal cancer: Open Targets association 0.52 with colorectal cancer (MONDO_0005575)
- Non-Hodgkin lymphoma: Open Targets association 0.52 with non-Hodgkin lymphoma (MONDO_0018908)
- Leukaemia: Open Targets association 0.51 with leukaemia (MONDO_0005059)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SND1" OR ABSTRACT:"SND1" OR TITLE:"staphylococcal nuclease and tudor domain containing 1" OR ABSTRACT:"staphylococcal nuclease and tudor domain containing 1" OR TITLE:"Staphylococcal nuclease domain-containing protein 1" OR ABSTRACT:"Staphylococcal nuclease domain-containing protein 1" OR TITLE:"TDRD11" OR ABSTRACT:"TDRD11" OR TITLE:"p100" OR ABSTRACT:"p100") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SND1, not a curated reading list.
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