SND1 (Staphylococcal nuclease domain-containing protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Cervical cancer, Breast cancer, Lung cancer and 3 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition. Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for STAT5. Location: Cytoplasm; Nucleus; Melanosome (UniProt). Locus 7q32.1 (HGNC).
- Cervical cancer: IntOGen driver in 1 cohort (CESC)
- Breast cancer: Open Targets association 0.56 with breast cancer (MONDO_0007254)
- Lung cancer: Open Targets association 0.54 with lung cancer (MONDO_0008903)
- Colorectal cancer: Open Targets association 0.52 with colorectal cancer (MONDO_0005575)
- Non-Hodgkin lymphoma: Open Targets association 0.52 with non-Hodgkin lymphoma (MONDO_0018908)
- Leukaemia: Open Targets association 0.51 with leukaemia (MONDO_0005059)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"SND1" OR ABSTRACT:"SND1" OR TITLE:"staphylococcal nuclease and tudor domain containing 1" OR ABSTRACT:"staphylococcal nuclease and tudor domain containing 1" OR TITLE:"Staphylococcal nuclease domain-containing protein 1" OR ABSTRACT:"Staphylococcal nuclease domain-containing protein 1" OR TITLE:"TDRD11" OR ABSTRACT:"TDRD11" OR TITLE:"p100" OR ABSTRACT:"p100") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SND1, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/snd1.json. Licence CC BY-NC 4.0.