TRIM49C
TRIM49C (Tripartite motif-containing protein 49C) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Gastric & gastro-oesophageal junction cancer.
Overview
UniProt has no function text for P0CI26; HGNC names it "tripartite motif containing 49C".
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Stomach Adenocarcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TRIM49C (Tripartite motif-containing protein 49C) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Gastric & gastro-oesophageal junction cancer.
- 1 · What it is
TRIM49C (Tripartite motif-containing protein 49C) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Gastric & gastro-oesophageal junction cancer.
- 2 · What goes wrong in cancer
UniProt has no function text for P0CI26; HGNC names it "tripartite motif containing 49C". Locus 11q14.3 (HGNC).
- 3 · How drugs use it
No product in this corpus aims at TRIM49C yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:38877 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P0CI26 (protein name, function text, keywords and locations (REST API)); IntOGen TRIM49C (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
UniProt has no function text for P0CI26; HGNC names it "tripartite motif containing 49C". Locus 11q14.3 (HGNC).
- Gastric & gastro-oesophageal junction cancer: IntOGen driver in 1 cohort (STAD)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TRIM49C" OR ABSTRACT:"TRIM49C" OR TITLE:"tripartite motif containing 49C" OR ABSTRACT:"tripartite motif containing 49C" OR TITLE:"Tripartite motif-containing protein 49C" OR ABSTRACT:"Tripartite motif-containing protein 49C" OR TITLE:"TRIM49L2" OR ABSTRACT:"TRIM49L2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TRIM49C, not a curated reading list.