CLIP1
CLIP1 (CAP-Gly domain-containing linker protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Lung cancer, Cervical cancer, Oesophageal cancer and 2 more.
Overview
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking.
Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.86, affected pathway 0.93, genetic association 0.00, somatic mutation 0.45). IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Cervical Squamous Cell Carcinoma, Oesophageal Squamous Cell Carcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CLIP1 (CAP-Gly domain-containing linker protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Lung cancer, Cervical cancer, Oesophageal cancer and 2 more.
- 1 · What it is
CLIP1 (CAP-Gly domain-containing linker protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Lung cancer, Cervical cancer, Oesophageal cancer and 2 more.
- 2 · What goes wrong in cancer
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling.
- 3 · How drugs use it
No product in this corpus aims at CLIP1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:10461 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P30622 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000130779 (association with cancer (MONDO_0004992) 0.66; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.59, lung cancer 0.60 (GraphQL API, CC0)); IntOGen CLIP1 (driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. Location: Cytoplasm; Cytoplasm, cytoskeleton; Cytoplasmic vesicle membrane; Cell projection, ruffle (UniProt). Locus 12q24.31 (HGNC).
- Lung cancer: Open Targets association 0.60 with lung cancer (MONDO_0008903)
- Cervical cancer: IntOGen driver in 1 cohort (CESC)
- Oesophageal cancer: IntOGen driver in 1 cohort (ESCC)
- Non-small-cell lung cancer: Open Targets association 0.59 with non-small cell lung carcinoma (MONDO_0005233)
- Oesophageal squamous cell carcinoma: IntOGen driver in 1 cohort (ESCC)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CLIP1" OR ABSTRACT:"CLIP1" OR TITLE:"CAP-Gly domain containing linker protein 1" OR ABSTRACT:"CAP-Gly domain containing linker protein 1" OR TITLE:"CAP-Gly domain-containing linker protein 1" OR ABSTRACT:"CAP-Gly domain-containing linker protein 1" OR TITLE:"CYLN1" OR ABSTRACT:"CYLN1" OR TITLE:"CLIP170" OR ABSTRACT:"CLIP170" OR TITLE:"CLIP-170" OR ABSTRACT:"CLIP-170") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CLIP1, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetZBTB16
Shares Oesophageal squamous cell carcinoma, Lung cancer (all types), Oesophageal cancer, IntOGen.
- TargetEIF3E
Shares Lung cancer (all types), Cervical cancer, IntOGen, Open Targets Platform.
- TargetLRIG3
Shares Lung cancer (all types), IntOGen, Open Targets Platform, Non-small-cell lung cancer.
- TargetRAP1GDS1
Shares Oesophageal squamous cell carcinoma, Oesophageal cancer, IntOGen, Open Targets Platform.
- TargetSLC34A2
Shares Lung cancer (all types), IntOGen, Open Targets Platform, Non-small-cell lung cancer.
- TargetNUTM1
Shares Lung cancer (all types), Oesophageal cancer, IntOGen, Open Targets Platform.
- TargetZNF521
Shares Lung cancer (all types), Oesophageal cancer, Cervical cancer, IntOGen.
- TargetCD74
Shares Lung cancer (all types), Open Targets Platform, Non-small-cell lung cancer.