LSM14A
LSM14A (Protein LSM14 homolog A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer.
Overview
Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation. Acts as a repressor of mRNA translation. May play a role in mitotic spindle assembly.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Endometrial Carcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · LSM14A (Protein LSM14 homolog A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer.
- 1 · What it is
LSM14A (Protein LSM14 homolog A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer.
- 2 · What goes wrong in cancer
Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation. Acts as a repressor of mRNA translation.
- 3 · How drugs use it
No product in this corpus aims at LSM14A yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:24489 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8ND56 (protein name, function text, keywords and locations (REST API)); IntOGen LSM14A (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation. Acts as a repressor of mRNA translation. May play a role in mitotic spindle assembly. Location: Cytoplasm, P-body; Cytoplasm, cytoskeleton, spindle; Cytoplasm, Stress granule (UniProt). Locus 19q13.11 (HGNC).
- Endometrial cancer: IntOGen driver in 1 cohort (UCEC)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"LSM14A" OR ABSTRACT:"LSM14A" OR TITLE:"LSM14A mRNA processing body assembly factor" OR ABSTRACT:"LSM14A mRNA processing body assembly factor" OR TITLE:"Protein LSM14 homolog A" OR ABSTRACT:"Protein LSM14 homolog A" OR TITLE:"DKFZP434D1335" OR ABSTRACT:"DKFZP434D1335" OR TITLE:"RAP55A" OR ABSTRACT:"RAP55A" OR TITLE:"RAP55" OR ABSTRACT:"RAP55") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LSM14A, not a curated reading list.