ETV5
ETV5 (ETS translocation variant 5) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Lung cancer, Pancreatic ductal adenocarcinoma, Neuroendocrine tumours and 4 more.
Overview
Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'.
CIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Trametinib. Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.20, somatic mutation 0.85). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Acute Myeloid Leukaemia.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ETV5 (ETS translocation variant 5) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Lung cancer, Pancreatic ductal adenocarcinoma, Neuroendocrine tumours and 4 more.
- 1 · What it is
ETV5 (ETS translocation variant 5) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Lung cancer, Pancreatic ductal adenocarcinoma, Neuroendocrine tumours and 4 more.
- 2 · What goes wrong in cancer
Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'. Location: Nucleus (UniProt).
- 3 · How drugs use it
No product in this corpus aims at ETV5 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:3494 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P41161 (protein name, function text, keywords and locations (REST API)); CIViC gene ETV5 (2 evidence items, 0 assertions, 1 variants; diseases: Lung Cancer, Pancreatic Cancer (GraphQL API, CC0)); Open Targets ENSG00000244405 (association with cancer (MONDO_0004992) 0.67; per-cancer scores at or above 0.5: colorectal cancer 0.51, neuroendocrine neoplasm 0.56, skin cancer 0.52, breast cancer 0.52 (GraphQL API, CC0)); IntOGen ETV5 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'. Location: Nucleus (UniProt). Locus 3q27.2 (HGNC).
- Lung cancer: CIViC evidence names this disease
- Pancreatic ductal adenocarcinoma: CIViC evidence names this disease
- Neuroendocrine tumours: Open Targets association 0.56 with neuroendocrine neoplasm (MONDO_0019496)
- Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898)
- Breast cancer: Open Targets association 0.52 with breast cancer (MONDO_0007254)
- Colorectal cancer: Open Targets association 0.51 with colorectal cancer (MONDO_0005575)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; IntOGen calls it an activating (Act) driver in 1 cohort; CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ETV5" OR ABSTRACT:"ETV5" OR TITLE:"ETS variant transcription factor 5" OR ABSTRACT:"ETS variant transcription factor 5" OR TITLE:"ETS translocation variant 5" OR ABSTRACT:"ETS translocation variant 5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ETV5, not a curated reading list.
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