ROBO2
ROBO2 (Roundabout homolog 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Prostate cancer, Renal cell carcinoma and 5 more.
Overview
Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development.
IntOGen calls it a driver in 16 cohorts (8 activating, 8 loss-of-function), covering Chromophobe Renal Cell Carcinoma, Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma, Colon Adenocarcinoma, Colorectal Adenocarcinoma, Oesophagogastric Adenocarcinoma, Oesophageal Adenocarcinoma and others.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ROBO2 (Roundabout homolog 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Prostate cancer, Renal cell carcinoma and 5 more.
- 1 · What it is
ROBO2 (Roundabout homolog 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Prostate cancer, Renal cell carcinoma and 5 more.
- 2 · What goes wrong in cancer
Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development.
- 3 · How drugs use it
No product in this corpus aims at ROBO2 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:10250 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9HCK4 (protein name, function text, keywords and locations (REST API)); IntOGen ROBO2 (driver in 16 cohorts (Act 8, LoF 8); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. Location: Membrane (UniProt). Locus 3p12.3 (HGNC).
- Colorectal cancer: IntOGen driver in 5 cohorts (COAD, COADREAD)
- Prostate cancer: IntOGen driver in 2 cohorts (PRAD)
- Renal cell carcinoma: IntOGen driver in 1 cohort (CHRCC)
- Gastric & gastro-oesophageal junction cancer: IntOGen driver in 1 cohort (EGC)
- Oesophageal cancer: IntOGen driver in 1 cohort (ESCA)
- Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 8 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 8 cohorts; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ROBO2" OR ABSTRACT:"ROBO2" OR TITLE:"roundabout guidance receptor 2" OR ABSTRACT:"roundabout guidance receptor 2" OR TITLE:"Roundabout homolog 2" OR ABSTRACT:"Roundabout homolog 2" OR TITLE:"KIAA1568" OR ABSTRACT:"KIAA1568") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ROBO2, not a curated reading list.