EBF1
EBF1 (Transcription factor COE1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Non-Hodgkin lymphoma, Neuroendocrine tumours and 4 more.
Overview
Key pioneer transcription factor of B-cell specification and commitment. Recognises variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.74 (direct and indirect evidence; datatypes literature 0.93, animal model 0.43, genetic association 0.62, somatic mutation 0.83). IntOGen calls it a driver in 6 cohorts (3 activating, 3 loss-of-function), covering Diffuse Large B-Cell Lymphoma, NOS, Lung Squamous Cell Carcinoma, Malignant Lymphoma, Non-Hodgkin Lymphoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · EBF1 (Transcription factor COE1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Non-Hodgkin lymphoma, Neuroendocrine tumours and 4 more.
- 1 · What it is
EBF1 (Transcription factor COE1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Non-Hodgkin lymphoma, Neuroendocrine tumours and 4 more.
- 2 · What goes wrong in cancer
Key pioneer transcription factor of B-cell specification and commitment. Recognises variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.
- 3 · How drugs use it
No product in this corpus aims at EBF1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:3126 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UH73 (protein name, function text, keywords and locations (REST API)); CIViC gene EBF1 (1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)); Open Targets ENSG00000164330 (association with cancer (MONDO_0004992) 0.74; per-cancer scores at or above 0.5: neuroendocrine neoplasm 0.55, diffuse large B-cell lymphoma 0.54, non-Hodgkin lymphoma 0.62, skin cancer 0.54, breast cancer 0.66, lung cancer 0.55 (GraphQL API, CC0)); IntOGen EBF1 (driver in 6 cohorts (Act 3, LoF 3); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Key pioneer transcription factor of B-cell specification and commitment. Recognises variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates. For instance, positively regulates many B-cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage. In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold. In addition, binds to the viral LMP1 proximal promoter and promotes its expression during latency. Location: Nucleus (UniProt). Locus 5q33.3 (HGNC).
- Breast cancer: Open Targets association 0.66 with breast cancer (MONDO_0007254)
- Non-Hodgkin lymphoma: Open Targets association 0.62 with non-Hodgkin lymphoma (MONDO_0018908); IntOGen driver in 2 cohorts (MLYM, NHL)
- Neuroendocrine tumours: Open Targets association 0.55 with neuroendocrine neoplasm (MONDO_0019496)
- Lung cancer: Open Targets association 0.55 with lung cancer (MONDO_0008903)
- Skin cancer: Open Targets association 0.54 with skin cancer (MONDO_0002898)
- Diffuse large B-cell lymphoma: Open Targets association 0.54 with diffuse large B-cell lymphoma (MONDO_0018905); CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 3 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 3 cohorts; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"EBF1" OR ABSTRACT:"EBF1" OR TITLE:"EBF transcription factor 1" OR ABSTRACT:"EBF transcription factor 1" OR TITLE:"Transcription factor COE1" OR ABSTRACT:"Transcription factor COE1" OR TITLE:"OLF1" OR ABSTRACT:"OLF1" OR TITLE:"COE1" OR ABSTRACT:"COE1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about EBF1, not a curated reading list.
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