HDAC4
HDAC4 (Histone deacetylase 4) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target and an oncogene driver, and an approved or late-stage drug is recorded against it. Tied to Skin cancer, Non-Hodgkin lymphoma, Multiple myeloma and 1 more.
Overview
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.42, somatic mutation 0.40, clinical 0.95). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Thymoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · HDAC4 (Histone deacetylase 4) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target and an oncogene driver, and an approved or late-stage drug is recorded against it. Tied to Skin cancer, Non-Hodgkin lymphoma, Multiple myeloma and 1 more.
- 1 · What it is
HDAC4 (Histone deacetylase 4) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target and an oncogene driver, and an approved or late-stage drug is recorded against it. Tied to Skin cancer, Non-Hodgkin lymphoma, Multiple myeloma and 1 more.
- 2 · What goes wrong in cancer
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).
- 3 · How drugs use it
No product in this corpus aims at HDAC4 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:14063 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P56524 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000068024 (association with cancer (MONDO_0004992) 0.69; per-cancer scores at or above 0.5: plasma cell myeloma 0.55, non-Hodgkin lymphoma 0.57, skin cancer 0.57 (GraphQL API, CC0)); IntOGen HDAC4 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1. Location: Nucleus; Cytoplasm (UniProt). Locus 2q37.3 (HGNC).
- Skin cancer: Open Targets association 0.57 with skin cancer (MONDO_0002898)
- Non-Hodgkin lymphoma: Open Targets association 0.57 with non-Hodgkin lymphoma (MONDO_0018908)
- Multiple myeloma: Open Targets association 0.55 with plasma cell myeloma (MONDO_0009693)
- Thymoma: IntOGen driver in 1 cohort (THYM)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.95; IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"HDAC4" OR ABSTRACT:"HDAC4" OR TITLE:"histone deacetylase 4" OR ABSTRACT:"histone deacetylase 4" OR TITLE:"Histone deacetylase 4" OR ABSTRACT:"Histone deacetylase 4" OR TITLE:"KIAA0288" OR ABSTRACT:"KIAA0288" OR TITLE:"HDAC-A" OR ABSTRACT:"HDAC-A" OR TITLE:"HDACA" OR ABSTRACT:"HDACA") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HDAC4, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetGTF2I
- TargetCNTRL
Shares Thymoma (WHO types A, AB, B1, B2 and B3), IntOGen, Open Targets Platform.
- TargetZMYM3
Shares Thymoma (WHO types A, AB, B1, B2 and B3), IntOGen, Open Targets Platform.