SLC34A2
SLC34A2 (Sodium-dependent phosphate transport protein 2B) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Lung cancer, Colorectal cancer, Non-small-cell lung cancer and 1 more.
Overview
Involved in actively transporting phosphate into cells via Na(+) cotransport.
Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes clinical 0.15, literature 0.96, genetic association 0.48, somatic mutation 0.86, animal model 0.28). IntOGen calls it a driver in 3 cohorts (2 activating, 1 loss-of-function), covering Acute Myeloid Leukaemia, Colorectal Adenocarcinoma, Lung Adenocarcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SLC34A2 (Sodium-dependent phosphate transport protein 2B) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Lung cancer, Colorectal cancer, Non-small-cell lung cancer and 1 more.
- 1 · What it is
SLC34A2 (Sodium-dependent phosphate transport protein 2B) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Lung cancer, Colorectal cancer, Non-small-cell lung cancer and 1 more.
- 2 · What goes wrong in cancer
Involved in actively transporting phosphate into cells via Na(+) cotransport. Location: Apical cell membrane (UniProt).
- 3 · How drugs use it
No product in this corpus aims at SLC34A2 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:11020 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O95436 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000157765 (association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.57, lung cancer 0.60 (GraphQL API, CC0)); IntOGen SLC34A2 (driver in 3 cohorts (Act 2, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Involved in actively transporting phosphate into cells via Na(+) cotransport. Location: Apical cell membrane (UniProt). Locus 4p15.2 (HGNC).
- Lung cancer: Open Targets association 0.60 with lung cancer (MONDO_0008903)
- Colorectal cancer: IntOGen driver in 1 cohort (COADREAD)
- Non-small-cell lung cancer: Open Targets association 0.57 with non-small cell lung carcinoma (MONDO_0005233); IntOGen driver in 1 cohort (LUAD)
- Acute myeloid leukaemia: IntOGen driver in 1 cohort (AML)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.15; IntOGen calls it an activating (Act) driver in 2 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SLC34A2" OR ABSTRACT:"SLC34A2" OR TITLE:"solute carrier family 34 member 2" OR ABSTRACT:"solute carrier family 34 member 2" OR TITLE:"Sodium-dependent phosphate transport protein 2B" OR ABSTRACT:"Sodium-dependent phosphate transport protein 2B" OR TITLE:"NAPI-3B" OR ABSTRACT:"NAPI-3B" OR TITLE:"NaPi-2b" OR ABSTRACT:"NaPi-2b" OR TITLE:"NPTIIb" OR ABSTRACT:"NPTIIb") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SLC34A2, not a curated reading list.
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