NUP98
NUP98 (Nuclear pore complex protein Nup98-Nup96) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Lung cancer, Leukaemia and 3 more.
Overview
Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC.
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.00, somatic mutation 0.82). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Lung Squamous Cell Carcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · NUP98 (Nuclear pore complex protein Nup98-Nup96) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Lung cancer, Leukaemia and 3 more.
- 1 · What it is
NUP98 (Nuclear pore complex protein Nup98-Nup96) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Lung cancer, Leukaemia and 3 more.
- 2 · What goes wrong in cancer
Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC.
- 3 · How drugs use it
No product in this corpus aims at NUP98 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:8068 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P52948 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000110713 (association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: melanoma 0.52, skin cancer 0.55, breast cancer 0.52, lung cancer 0.54, leukaemia 0.54 (GraphQL API, CC0)); IntOGen NUP98 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes. Involved in the localisation of DHX9 in discrete intranuclear foci (GLFG-body). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro). Location: Nucleus membrane; Nucleus, nuclear pore complex; Nucleus, nucleoplasm (UniProt). Locus 11p15.4 (HGNC).
- Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)
- Lung cancer: Open Targets association 0.54 with lung cancer (MONDO_0008903)
- Leukaemia: Open Targets association 0.54 with leukaemia (MONDO_0005059)
- Breast cancer: Open Targets association 0.52 with breast cancer (MONDO_0007254)
- Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUSC)
- Melanoma: Open Targets association 0.52 with melanoma (MONDO_0005105)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"NUP98" OR ABSTRACT:"NUP98" OR TITLE:"nucleoporin 98 and 96 precursor" OR ABSTRACT:"nucleoporin 98 and 96 precursor" OR TITLE:"Nuclear pore complex protein Nup98-Nup96" OR ABSTRACT:"Nuclear pore complex protein Nup98-Nup96" OR TITLE:"NUP96" OR ABSTRACT:"NUP96" OR TITLE:"Nup98-Nup96" OR ABSTRACT:"Nup98-Nup96" OR TITLE:"Nup98-96" OR ABSTRACT:"Nup98-96") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NUP98, not a curated reading list.
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