CLTCL1
CLTCL1 (Clathrin heavy chain 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Prostate cancer, Skin cancer and 2 more.
Overview
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.31, genetic association 0.08, somatic mutation 0.84). IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Hepatocellular Carcinoma, Prostate Adenocarcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CLTCL1 (Clathrin heavy chain 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Prostate cancer, Skin cancer and 2 more.
- 1 · What it is
CLTCL1 (Clathrin heavy chain 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Prostate cancer, Skin cancer and 2 more.
- 2 · What goes wrong in cancer
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.
- 3 · How drugs use it
No product in this corpus aims at CLTCL1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:2093 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P53675 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000070371 (association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: skin cancer 0.52, breast cancer 0.51, lung cancer 0.51 (GraphQL API, CC0)); IntOGen CLTCL1 (driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Location: Cytoplasmic vesicle membrane; Membrane, coated pit (UniProt). Locus 22q11.21 (HGNC).
- Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)
- Prostate cancer: IntOGen driver in 1 cohort (PRAD)
- Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898)
- Lung cancer: Open Targets association 0.51 with lung cancer (MONDO_0008903)
- Breast cancer: Open Targets association 0.51 with breast cancer (MONDO_0007254)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CLTCL1" OR ABSTRACT:"CLTCL1" OR TITLE:"clathrin heavy chain like 1" OR ABSTRACT:"clathrin heavy chain like 1" OR TITLE:"Clathrin heavy chain 2" OR ABSTRACT:"Clathrin heavy chain 2" OR TITLE:"CLH22" OR ABSTRACT:"CLH22" OR TITLE:"CHC22" OR ABSTRACT:"CHC22" OR TITLE:"CLTCL" OR ABSTRACT:"CLTCL") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CLTCL1, not a curated reading list.
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