FNDC3B
FNDC3B (Fibronectin type III domain-containing protein 3B) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-Hodgkin lymphoma.
Overview
May be a positive regulator of adipogenesis.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Lymphoid Neoplasm.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FNDC3B (Fibronectin type III domain-containing protein 3B) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-Hodgkin lymphoma.
- 1 · What it is
FNDC3B (Fibronectin type III domain-containing protein 3B) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-Hodgkin lymphoma.
- 2 · What goes wrong in cancer
May be a positive regulator of adipogenesis. Location: Membrane (UniProt).
- 3 · How drugs use it
No product in this corpus aims at FNDC3B yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:24670 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q53EP0 (protein name, function text, keywords and locations (REST API)); IntOGen FNDC3B (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
May be a positive regulator of adipogenesis. Location: Membrane (UniProt). Locus 3q26.31 (HGNC).
- Non-Hodgkin lymphoma: IntOGen driver in 1 cohort (LNM)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"FNDC3B" OR ABSTRACT:"FNDC3B" OR TITLE:"fibronectin type III domain containing 3B" OR ABSTRACT:"fibronectin type III domain containing 3B" OR TITLE:"Fibronectin type III domain-containing protein 3B" OR ABSTRACT:"Fibronectin type III domain-containing protein 3B" OR TITLE:"FAD104" OR ABSTRACT:"FAD104" OR TITLE:"DKFZp762K137" OR ABSTRACT:"DKFZp762K137" OR TITLE:"FLJ23399" OR ABSTRACT:"FLJ23399") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FNDC3B, not a curated reading list.