TFRC
TFRC (Transferrin receptor protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer and Non-small-cell lung cancer.
Overview
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialised endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor.
IntOGen calls it a driver in 2 cohorts (1 activating, 1 loss-of-function), covering Non-Small Cell Lung Cancer, Prostate Adenocarcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TFRC (Transferrin receptor protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer and Non-small-cell lung cancer.
- 1 · What it is
TFRC (Transferrin receptor protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer and Non-small-cell lung cancer.
- 2 · What goes wrong in cancer
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialised endosomes. Endosomal acidification leads to iron release.
- 3 · How drugs use it
No product in this corpus aims at TFRC yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:11763 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P02786 (protein name, function text, keywords and locations (REST API)); IntOGen TFRC (driver in 2 cohorts (Act 1, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialised endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the hereditary haemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake. Location: Cell membrane; Melanosome; Secreted (UniProt). Locus 3q29 (HGNC).
- Prostate cancer: IntOGen driver in 1 cohort (PRAD)
- Non-small-cell lung cancer: IntOGen driver in 1 cohort (NSCLC)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TFRC" OR ABSTRACT:"TFRC" OR TITLE:"transferrin receptor" OR ABSTRACT:"transferrin receptor" OR TITLE:"Transferrin receptor protein 1" OR ABSTRACT:"Transferrin receptor protein 1" OR TITLE:"CD71" OR ABSTRACT:"CD71" OR TITLE:"TFR1" OR ABSTRACT:"TFR1" OR TITLE:"p90" OR ABSTRACT:"p90") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TFRC, not a curated reading list.