MYH11
MYH11 (Myosin-11) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Breast cancer, Head and neck squamous cell carcinoma and 5 more.
Overview
Muscle contraction.
IntOGen calls it a driver in 10 cohorts (5 activating, 5 loss-of-function), covering Acute Myeloid Leukaemia, Invasive Breast Carcinoma, Cholangiocarcinoma, Head and Neck Squamous Cell Carcinoma, Low-Grade Glioma, NOS, Melanoma and others.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MYH11 (Myosin-11) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Breast cancer, Head and neck squamous cell carcinoma and 5 more.
- 1 · What it is
MYH11 (Myosin-11) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Breast cancer, Head and neck squamous cell carcinoma and 5 more.
- 2 · What goes wrong in cancer
Muscle contraction. Location: Melanosome (UniProt).
- 3 · How drugs use it
No product in this corpus aims at MYH11 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:7569 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P35749 (protein name, function text, keywords and locations (REST API)); IntOGen MYH11 (driver in 10 cohorts (Act 5, LoF 5); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Muscle contraction. Location: Melanosome (UniProt). Locus 16p13.11 (HGNC).
- Prostate cancer: IntOGen driver in 2 cohorts (PRAD, PROSTATE)
- Breast cancer: IntOGen driver in 1 cohort (BRCA)
- Head and neck squamous cell carcinoma: IntOGen driver in 1 cohort (HNSC)
- Nasopharyngeal carcinoma: IntOGen driver in 1 cohort (NPC)
- Sarcomas: IntOGen driver in 1 cohort (SOFT_TISSUE)
- Acute myeloid leukaemia: IntOGen driver in 1 cohort (AML)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 5 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 5 cohorts; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Low-Grade Glioma, NOS.
Latest papers
topQuery for this target: (TITLE:"MYH11" OR ABSTRACT:"MYH11" OR TITLE:"myosin heavy chain 11" OR ABSTRACT:"myosin heavy chain 11" OR TITLE:"Myosin-11" OR ABSTRACT:"Myosin-11" OR TITLE:"SMMHC" OR ABSTRACT:"SMMHC" OR TITLE:"SMMS-1" OR ABSTRACT:"SMMS-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MYH11, not a curated reading list.
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