BMPR1A
BMPR1A (Bone morphogenetic protein receptor type-1A) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Gastric & gastro-oesophageal junction cancer, Colorectal cancer, Breast cancer and 1 more.
Overview
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6.
Open Targets scores its association with cancer at 0.77 (direct and indirect evidence; datatypes literature 0.90, genetic association 0.69, somatic mutation 0.83, genetic literature 0.61). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Stomach Adenocarcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · BMPR1A (Bone morphogenetic protein receptor type-1A) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Gastric & gastro-oesophageal junction cancer, Colorectal cancer, Breast cancer and 1 more.
- 1 · What it is
BMPR1A (Bone morphogenetic protein receptor type-1A) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Gastric & gastro-oesophageal junction cancer, Colorectal cancer, Breast cancer and 1 more.
- 2 · What goes wrong in cancer
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases.
- 3 · How drugs use it
No product in this corpus aims at BMPR1A yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
External identifiers
Sources: HGNC HGNC:1076 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P36894 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000107779 (association with cancer (MONDO_0004992) 0.77; per-cancer scores at or above 0.5: colorectal cancer 0.56, ovarian cancer 0.54, breast cancer 0.55 (GraphQL API, CC0)); IntOGen BMPR1A (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. May promote the expression of HAMP, potentially via its interaction with BMP2. Location: Cell membrane; Cell surface (UniProt). Locus 10q23.2 (HGNC).
- Gastric & gastro-oesophageal junction cancer: IntOGen driver in 1 cohort (STAD)
- Colorectal cancer: Open Targets association 0.56 with colorectal cancer (MONDO_0005575)
- Breast cancer: Open Targets association 0.55 with breast cancer (MONDO_0007254)
- Ovarian cancer: Open Targets association 0.54 with ovarian cancer (MONDO_0008170)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"BMPR1A" OR ABSTRACT:"BMPR1A" OR TITLE:"bone morphogenetic protein receptor type 1A" OR ABSTRACT:"bone morphogenetic protein receptor type 1A" OR TITLE:"Bone morphogenetic protein receptor type-1A" OR ABSTRACT:"Bone morphogenetic protein receptor type-1A" OR TITLE:"ALK3" OR ABSTRACT:"ALK3" OR TITLE:"CD292" OR ABSTRACT:"CD292" OR TITLE:"ACVRLK3" OR ABSTRACT:"ACVRLK3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BMPR1A, not a curated reading list.