HOXC13
HOXC13 (Homeobox protein Hox-C13) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer.
Overview
Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes.
Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.93, animal model 0.67, somatic mutation 0.77). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Invasive Breast Carcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · HOXC13 (Homeobox protein Hox-C13) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer.
- 1 · What it is
HOXC13 (Homeobox protein Hox-C13) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer.
- 2 · What goes wrong in cancer
Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes.
- 3 · How drugs use it
No product in this corpus aims at HOXC13 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:5125 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P31276 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000123364 (association with cancer (MONDO_0004992) 0.60; (GraphQL API, CC0)); IntOGen HOXC13 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes. Location: Nucleus (UniProt). Locus 12q13.13 (HGNC).
- Breast cancer: IntOGen driver in 1 cohort (BRCA)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"HOXC13" OR ABSTRACT:"HOXC13" OR TITLE:"homeobox C13" OR ABSTRACT:"homeobox C13" OR TITLE:"Homeobox protein Hox-C13" OR ABSTRACT:"Homeobox protein Hox-C13" OR TITLE:"HOX3" OR ABSTRACT:"HOX3" OR TITLE:"HOX3G" OR ABSTRACT:"HOX3G") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HOXC13, not a curated reading list.