MGA
MGA (MAX gene-associated protein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Mesothelioma, Prostate cancer, Diffuse large B-cell lymphoma and 3 more.
Overview
Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. IntOGen calls it a driver in 5 cohorts (0 activating, 5 loss-of-function), covering Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma, Lung Adenocarcinoma, Pleural Mesothelioma, Prostate Adenocarcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MGA (MAX gene-associated protein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Mesothelioma, Prostate cancer, Diffuse large B-cell lymphoma and 3 more.
- 1 · What it is
MGA (MAX gene-associated protein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Mesothelioma, Prostate cancer, Diffuse large B-cell lymphoma and 3 more.
- 2 · What goes wrong in cancer
Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator.
- 3 · How drugs use it
No product in this corpus aims at MGA yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:14010 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8IWI9 (protein name, function text, keywords and locations (REST API)); CIViC gene MGA (1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)); IntOGen MGA (driver in 5 cohorts (Act 0, LoF 5); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerisation with MAX. This heterodimerisation serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor. Location: Nucleus (UniProt). Locus 15q15 (HGNC).
- Mesothelioma: IntOGen driver in 1 cohort (PLMESO)
- Prostate cancer: IntOGen driver in 1 cohort (PRAD)
- Diffuse large B-cell lymphoma: CIViC evidence names this disease
- Chronic lymphocytic leukaemia: IntOGen driver in 2 cohorts (CLLSLL)
- Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUAD)
- Pleural mesothelioma: IntOGen driver in 1 cohort (PLMESO)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 5 cohorts; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"MGA" OR ABSTRACT:"MGA" OR TITLE:"MAX dimerization protein MGA" OR ABSTRACT:"MAX dimerization protein MGA" OR TITLE:"MAX gene-associated protein" OR ABSTRACT:"MAX gene-associated protein" OR TITLE:"KIAA0518" OR ABSTRACT:"KIAA0518" OR TITLE:"MAD5" OR ABSTRACT:"MAD5" OR TITLE:"MXD5" OR ABSTRACT:"MXD5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MGA, not a curated reading list.
Similar pages
not linked directly; found by shared links- TrialTT-4 and TT-10 as Single Agents and in Combination in Subjects With Advanced Selected Solid Tumors and Pleural Mesothelioma
Shares Pleural mesothelioma, Mesothelioma, Prostate cancer, Non-small-cell lung cancer.
- TargetHLA-DQA1
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
- TargetPDZD2
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
- TargetPI4KA
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
- TargetSHTN1
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
- TargetSRGAP3
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
- TargetCYP2C8
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
- TargetTAF15
Shares Pleural mesothelioma, Mesothelioma, IntOGen.