TFG
TFG (trafficking from ER to golgi regulator) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma and Lung cancer.
Overview
Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.
Open Targets scores its association with cancer at 0.74 (direct and indirect evidence; datatypes literature 0.86, affected pathway 0.93, genetic association 0.08, somatic mutation 0.79). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Hepatocellular Carcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TFG (trafficking from ER to golgi regulator) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma and Lung cancer.
- 1 · What it is
TFG (trafficking from ER to golgi regulator) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma and Lung cancer.
- 2 · What goes wrong in cancer
Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.
- 3 · How drugs use it
No product in this corpus aims at TFG yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:11758 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q92734 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000114354 (association with cancer (MONDO_0004992) 0.74; per-cancer scores at or above 0.5: lung cancer 0.51 (GraphQL API, CC0)); IntOGen TFG (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Location: Endoplasmic reticulum (UniProt). Locus 3q12.2 (HGNC).
- Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)
- Lung cancer: Open Targets association 0.51 with lung cancer (MONDO_0008903)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TFG" OR ABSTRACT:"TFG" OR TITLE:"trafficking from ER to golgi regulator" OR ABSTRACT:"trafficking from ER to golgi regulator" OR TITLE:"TF6" OR ABSTRACT:"TF6" OR TITLE:"FLJ36137" OR ABSTRACT:"FLJ36137" OR TITLE:"SPG57" OR ABSTRACT:"SPG57") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TFG, not a curated reading list.
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