HSP90AB1
HSP90AB1 (Heat shock protein HSP 90-beta) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.
Overview
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Melanoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · HSP90AB1 (Heat shock protein HSP 90-beta) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.
- 1 · What it is
HSP90AB1 (Heat shock protein HSP 90-beta) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.
- 2 · What goes wrong in cancer
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction.
- 3 · How drugs use it
No product in this corpus aims at HSP90AB1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:5258 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P08238 (protein name, function text, keywords and locations (REST API)); IntOGen HSP90AB1 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. Location: Cytoplasm; Melanosome; Nucleus; Secreted (UniProt). Locus 6p21.1 (HGNC).
- Melanoma: IntOGen driver in 1 cohort (MEL)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"HSP90AB1" OR ABSTRACT:"HSP90AB1" OR TITLE:"heat shock protein 90 alpha family class B member 1" OR ABSTRACT:"heat shock protein 90 alpha family class B member 1" OR TITLE:"Heat shock protein HSP 90-beta" OR ABSTRACT:"Heat shock protein HSP 90-beta" OR TITLE:"HSPC2" OR ABSTRACT:"HSPC2" OR TITLE:"HSPCB" OR ABSTRACT:"HSPCB") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HSP90AB1, not a curated reading list.