TMSB4X
TMSB4X (Thymosin beta-4) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma and Diffuse large B-cell lymphoma.
Overview
Plays an important role in the organisation of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerisation. Potent inhibitor of bone marrow derived stem cell differentiation.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. IntOGen calls it a driver in 6 cohorts (1 activating, 5 loss-of-function), covering Diffuse Large B-Cell Lymphoma, NOS, Malignant Lymphoma, Non-Hodgkin Lymphoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TMSB4X (Thymosin beta-4) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma and Diffuse large B-cell lymphoma.
- 1 · What it is
TMSB4X (Thymosin beta-4) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma and Diffuse large B-cell lymphoma.
- 2 · What goes wrong in cancer
Plays an important role in the organisation of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerisation.
- 3 · How drugs use it
No product in this corpus aims at TMSB4X yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:11881 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P62328 (protein name, function text, keywords and locations (REST API)); CIViC gene TMSB4X (1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)); Open Targets ENSG00000205542 (per-cancer scores at or above 0.5: diffuse large B-cell lymphoma 0.53, non-Hodgkin lymphoma 0.58 (GraphQL API, CC0)); IntOGen TMSB4X (driver in 6 cohorts (Act 1, LoF 5); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Plays an important role in the organisation of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerisation. Potent inhibitor of bone marrow derived stem cell differentiation. Acts by inhibits the entry of haematopoietic pluripotent stem cells into the S-phase. Location: Cytoplasm, cytoskeleton (UniProt). Locus Xp22.2 (HGNC).
- Non-Hodgkin lymphoma: Open Targets association 0.58 with non-Hodgkin lymphoma (MONDO_0018908); IntOGen driver in 2 cohorts (MLYM, NHL)
- Diffuse large B-cell lymphoma: Open Targets association 0.53 with diffuse large B-cell lymphoma (MONDO_0018905); CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 5 cohorts; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TMSB4X" OR ABSTRACT:"TMSB4X" OR TITLE:"thymosin beta 4 X-linked" OR ABSTRACT:"thymosin beta 4 X-linked" OR TITLE:"Thymosin beta-4" OR ABSTRACT:"Thymosin beta-4" OR TITLE:"TB4X" OR ABSTRACT:"TB4X" OR TITLE:"TMSB4" OR ABSTRACT:"TMSB4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TMSB4X, not a curated reading list.