MUC6
MUC6 (Mucin-6) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Acute myeloid leukaemia and Non-small-cell lung cancer.
Overview
May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumour markers in a variety of cancers. May play a role in epithelial organogenesis.
IntOGen calls it a driver in 3 cohorts (3 activating, 0 loss-of-function), covering Acute Myeloid Leukaemia, Hepatocellular Carcinoma, Lung Squamous Cell Carcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MUC6 (Mucin-6) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Acute myeloid leukaemia and Non-small-cell lung cancer.
- 1 · What it is
MUC6 (Mucin-6) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Acute myeloid leukaemia and Non-small-cell lung cancer.
- 2 · What goes wrong in cancer
May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen.
- 3 · How drugs use it
No product in this corpus aims at MUC6 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:7517 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6W4X9 (protein name, function text, keywords and locations (REST API)); IntOGen MUC6 (driver in 3 cohorts (Act 3, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumour markers in a variety of cancers. May play a role in epithelial organogenesis. Location: Secreted (UniProt). Locus 11p15.5 (HGNC).
- Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)
- Acute myeloid leukaemia: IntOGen driver in 1 cohort (AML)
- Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUSC)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 3 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"MUC6" OR ABSTRACT:"MUC6" OR TITLE:"mucin 6, oligomeric mucus/gel-forming gene/pseudogene" OR ABSTRACT:"mucin 6, oligomeric mucus/gel-forming gene/pseudogene" OR TITLE:"Mucin-6" OR ABSTRACT:"Mucin-6" OR TITLE:"MUC-6" OR ABSTRACT:"MUC-6") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MUC6, not a curated reading list.