FAT2
FAT2 (Protocadherin Fat 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Vulvar cancer.
Overview
Involved in the regulation of cell migration. May be involved in mediating the organisation of the parallel fibres of granule cells during cerebellar development.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Vulva/Vagina.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FAT2 (Protocadherin Fat 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Vulvar cancer.
- 1 · What it is
FAT2 (Protocadherin Fat 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Vulvar cancer.
- 2 · What goes wrong in cancer
Involved in the regulation of cell migration. May be involved in mediating the organisation of the parallel fibres of granule cells during cerebellar development.
- 3 · How drugs use it
No product in this corpus aims at FAT2 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:3596 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NYQ8 (protein name, function text, keywords and locations (REST API)); IntOGen FAT2 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Involved in the regulation of cell migration. May be involved in mediating the organisation of the parallel fibres of granule cells during cerebellar development. Location: Cell membrane; Cell junction; Golgi apparatus, trans-Golgi network (UniProt). Locus 5q33.1 (HGNC).
- Vulvar cancer: IntOGen driver in 1 cohort (VULVA)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"FAT2" OR ABSTRACT:"FAT2" OR TITLE:"FAT atypical cadherin 2" OR ABSTRACT:"FAT atypical cadherin 2" OR TITLE:"Protocadherin Fat 2" OR ABSTRACT:"Protocadherin Fat 2" OR TITLE:"MEGF1" OR ABSTRACT:"MEGF1" OR TITLE:"CDHF8" OR ABSTRACT:"CDHF8" OR TITLE:"HFAT2" OR ABSTRACT:"HFAT2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FAT2, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetKMT2B
Shares Vulvar cancer, IntOGen.
- TargetZFHX3
Shares Vulvar cancer, IntOGen.
- TargetBCL11B
Shares Vulvar cancer, IntOGen.
- TargetMAML2
Shares Vulvar cancer, IntOGen.