CSMD3
CSMD3 (CUB and sushi domain-containing protein 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Hepatocellular carcinoma, Head and neck squamous cell carcinoma and 5 more.
Overview
Involved in dendrite development.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.42, genetic association 0.51, somatic mutation 0.76). IntOGen calls it a driver in 46 cohorts (26 activating, 19 loss-of-function), covering Bladder Urothelial Carcinoma, Invasive Breast Carcinoma, Colon Adenocarcinoma, Colorectal Adenocarcinoma, Oesophageal Adenocarcinoma, Glioblastoma Multiforme and others.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CSMD3 (CUB and sushi domain-containing protein 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Hepatocellular carcinoma, Head and neck squamous cell carcinoma and 5 more.
- 1 · What it is
CSMD3 (CUB and sushi domain-containing protein 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Hepatocellular carcinoma, Head and neck squamous cell carcinoma and 5 more.
- 2 · What goes wrong in cancer
Involved in dendrite development. Location: Cell membrane (UniProt).
- 3 · How drugs use it
No product in this corpus aims at CSMD3 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:19291 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q7Z407 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000164796 (association with cancer (MONDO_0004992) 0.63; (GraphQL API, CC0)); IntOGen CSMD3 (driver in 46 cohorts (Act 26, LoF 19); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Involved in dendrite development. Location: Cell membrane (UniProt). Locus 8q23.3 (HGNC).
- Prostate cancer: IntOGen driver in 9 cohorts (PRAD)
- Hepatocellular carcinoma: IntOGen driver in 4 cohorts (HCC)
- Head and neck squamous cell carcinoma: IntOGen driver in 4 cohorts (HNSC)
- Gastric & gastro-oesophageal junction cancer: IntOGen driver in 4 cohorts (STAD)
- Breast cancer: IntOGen driver in 3 cohorts (BRCA)
- Colorectal cancer: IntOGen driver in 3 cohorts (COAD, COADREAD)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 26 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 19 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CSMD3" OR ABSTRACT:"CSMD3" OR TITLE:"CUB and Sushi multiple domains 3" OR ABSTRACT:"CUB and Sushi multiple domains 3" OR TITLE:"CUB and sushi domain-containing protein 3" OR ABSTRACT:"CUB and sushi domain-containing protein 3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CSMD3, not a curated reading list.