MYEOV
MYEOV (Myeloma-overexpressed gene protein) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer.
Overview
UniProt has no function text for Q96EZ4; HGNC names it "myeloma overexpressed".
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.91, genetic association 0.62, somatic mutation 0.23). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Prostate Adenocarcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MYEOV (Myeloma-overexpressed gene protein) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer.
- 1 · What it is
MYEOV (Myeloma-overexpressed gene protein) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer.
- 2 · What goes wrong in cancer
UniProt has no function text for Q96EZ4; HGNC names it "myeloma overexpressed". Locus 11q13.3 (HGNC).
- 3 · How drugs use it
No product in this corpus aims at MYEOV yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:7563 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96EZ4 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000172927 (association with cancer (MONDO_0004992) 0.52; (GraphQL API, CC0)); IntOGen MYEOV (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
UniProt has no function text for Q96EZ4; HGNC names it "myeloma overexpressed". Locus 11q13.3 (HGNC).
- Prostate cancer: IntOGen driver in 1 cohort (PRAD)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"MYEOV" OR ABSTRACT:"MYEOV" OR TITLE:"myeloma overexpressed" OR ABSTRACT:"myeloma overexpressed" OR TITLE:"Myeloma-overexpressed gene protein" OR ABSTRACT:"Myeloma-overexpressed gene protein") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MYEOV, not a curated reading list.