SNX29
SNX29 (Sorting nexin-29) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer and Small intestine cancer.
Overview
UniProt has no function text for Q8TEQ0; HGNC names it "sorting nexin 29".
IntOGen calls it a driver in 2 cohorts (1 activating, 1 loss-of-function), covering Bladder Urothelial Carcinoma, Small Intestinal Carcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SNX29 (Sorting nexin-29) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer and Small intestine cancer.
- 1 · What it is
SNX29 (Sorting nexin-29) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer and Small intestine cancer.
- 2 · What goes wrong in cancer
UniProt has no function text for Q8TEQ0; HGNC names it "sorting nexin 29". Locus 16p13.13-p13.12 (HGNC).
- 3 · How drugs use it
No product in this corpus aims at SNX29 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:30542 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8TEQ0 (protein name, function text, keywords and locations (REST API)); IntOGen SNX29 (driver in 2 cohorts (Act 1, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
UniProt has no function text for Q8TEQ0; HGNC names it "sorting nexin 29". Locus 16p13.13-p13.12 (HGNC).
- Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA)
- Small intestine cancer: IntOGen driver in 1 cohort (SIC)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SNX29" OR ABSTRACT:"SNX29" OR TITLE:"sorting nexin 29" OR ABSTRACT:"sorting nexin 29" OR TITLE:"Sorting nexin-29" OR ABSTRACT:"Sorting nexin-29" OR TITLE:"FLJ12363" OR ABSTRACT:"FLJ12363" OR TITLE:"RUNDC2A" OR ABSTRACT:"RUNDC2A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SNX29, not a curated reading list.
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